The California Highway Patrol received a call around 3:18 a.m. about the crash, which occurred at the Los Feliz Boulevard off-ramp.
The 25-year-old man was pronounced dead at the scene after being ejected from his vehicle, the Los Angeles Fire Department said. A 61-year-old man, 35-year-old man and two 22-year-old men were taken to hospitals in fair condition. A 28-year-old man was transported to a hospital in serious condition, the LAFD said.
The cause of the crash is still under investigation, said Officer John Trejos of the CHP.
Three lanes on the northbound stretch of the 5 Freeway at Los Feliz Boulevard remained closed midmorning because of the incident, he said.
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